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Literature summary for 1.14.15.6 extracted from

  • Nguyen, M.N.; Slominski, A.; Li, W.; Ng, Y.R.; Tuckey, R.C.
    Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1) (2009), Drug Metab. Dispos., 37, 761-767.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
17,20-dihydroxyvitamin D2 competitive inhibitor Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0091
-
cholesterol in 0.45% cyclodextrin Bos taurus
0.012
-
20-hydroxyvitamin D2 in 0.45% cyclodextrin Bos taurus
0.0175
-
vitamin D2 in 0.45% cyclodextrin Bos taurus
0.0181
-
17,20-dihydroxyvitamin D2 in 0.45% cyclodextrin Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17,20-dihydroxyvitamin D2 + reduced adrenodoxin + O2 is slowly metabolized Bos taurus 17,20,24-trihydroxyvitamin D2 + oxidized adrenodoxin + O2
-
?
20-hydroxyvitamin D2 + reduced adrenodoxin + O2 is a better substrate than vitamin D2 itself Bos taurus 17,20,24-trihydroxyvitamin D2 + oxidized adrenodoxin + O2
-
?
cholesterol + reduced adrenodoxin + O2
-
Bos taurus pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O
-
?
vitamin D2 + reduced adrenodoxin + O2 P450scc catalyzes three sequential hydroxylations of D2 producing 20-hydroxyvitamin D2, 17,20-dihydroxyvitamin D2, and 17,20,24-trihydroxyvitamin D2, which dissociate from the active site of P450scc and accumulate in the reaction mixture Bos taurus 17,20,24-trihydroxyvitamin D2 + oxidized adrenodoxin + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP11A1
-
Bos taurus
cytochrome P450scc
-
Bos taurus
P450scc
-
Bos taurus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information in 0.45% cyclodextrin, the kcat of cholesterol is 6.1 mol/min/mol P450scc, the kcat of vitamin D2 is 2.28 mol/min/mol P450scc, the kcat of 20-hydroxyvitamin D2 is 2.47 mol/min/mol P450scc and the kcat of 17,20-dihydroxyvitamin D2 is 0.33 mol/min/mol P450scc. In phosphatidylcholine vesicles, the kcat of cholesterol is 46 mol/min/mol P450scc, the kcat of vitamin D2 is 5.62 mol/min/mol P450scc, the kcat of 20-hydroxyvitamin D2 is 1.99 mol/min/mol P450scc and the kcat of 17,20-dihydroxyvitamin D2 is 0.21 mol/min/mol P450scc Bos taurus

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
Bos taurus

General Information

General Information Comment Organism
metabolism vitamin D2 metabolism occurs with lower efficiency than that observed for both cholesterol and D3 metabolism by P450scc Bos taurus