Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-dihydroxynaphthalene | binds to Fe3+ on enzyme that is oxidized during catalysis | Rattus norvegicus | |
Acetohydroxamate | competitive vs. tetrahydrobiopterin, most probably due to chelation of enzyme's iron | Rattus norvegicus | |
bathophenanthroline | competitive vs. 6-methyl-5,6,7,8-tetrahydropterin and tetrahydrobiopterin, most probably due to chelation of enzyme's iron | Rattus norvegicus | |
benzohydroxamate | competitive vs. tetrahydrobiopterin, most probably due to chelation of enzyme's iron | Rattus norvegicus | |
o-phenanthroline | 1 mM, removes Fe2+ from the reduced enzyme | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | kinetic data suggest, that enzyme's iron is solvent-accessible and resides in a hydrophobic pocket of the enzyme | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000015 | - |
bathophenanthroline | vs. tetrahydrobiopterin | Rattus norvegicus | |
0.0000018 | - |
bathophenanthroline | vs. 6-methyl-5,6,7,8-tetrahydropterin | Rattus norvegicus | |
0.07 | - |
benzohydroxamate | - |
Rattus norvegicus | |
1.7 | - |
Acetohydroxamate | - |
Rattus norvegicus |