Literature summary for 1.14.16.1 extracted from

Shiman, R.; Xia, T.; Hill, M.A.; Gray, D.W.
Regulation of rat liver phenylalanine hydroxylase. II. Substrate binding and the role of activation in the control of enzymic activity (1994), J. Biol. Chem., 269, 24647-24656.

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Activating Compound

Activating Compound	Comment	Organism	Structure
phenylalanine	binds to activation site distinct from catalytic site with a stoichiometry of 1/enzyme subunit, binding induces a conformation change converting the enzyme tetramer from an inactive to an active form, activation site binds phenylalanine in a cooperative manner, regulation of activation	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(6R)-L-erythro-tetrahydrobiopterin	modulator that inhibits activation	Rattus norvegicus
deaza-6-methyltetrahydropterin	competitive vs. 6-methyltetrahydropterin	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.026	-	deaza-6-methyltetrahydropterin	-	Rattus norvegicus

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Release 2023.1 (January 2023)