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Literature summary for 1.14.16.1 extracted from

  • Patel, N.G.; Iliadou, C.; Boonyapiwat, B.; Barlow, D.J.; Forbes, B.; Mitchell, S.C.; Steventon, G.B.
    Enzyme kinetic and molecular modelling studies of sulphur-containing substrates of phenylalanine 4-monooxygenase (2007), J. Enzyme Inhib. Med. Chem., 23, 958-63.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic and molecular modelling of sulfur-containing substrates, overview Homo sapiens
additional information
-
additional information kinetic and molecular modelling of sulfur-containing substrates, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine + tetrahydrobiopterin + O2 Homo sapiens
-
L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
?
L-phenylalanine + tetrahydrobiopterin + O2 Rattus norvegicus
-
L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
?
additional information Homo sapiens the enzyme is important in the metabolism of xenobiotic thioether substrates, overview ?
-
?
additional information Rattus norvegicus the enzyme is important in the metabolism of xenobiotic thioether substrates, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + tetrahydrobiopterin + O2
-
Homo sapiens L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
?
L-phenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
?
L-thienylalanine + tetrahydrobiopterin + O2
-
Homo sapiens ?
-
?
L-thienylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
additional information the enzyme is important in the metabolism of xenobiotic thioether substrates, overview Homo sapiens ?
-
?
additional information the enzyme is important in the metabolism of xenobiotic thioether substrates, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PAH
-
Homo sapiens
PAH
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
Homo sapiens
tetrahydrobiopterin
-
Rattus norvegicus