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Literature summary for 1.14.16.2 extracted from

  • Richtand, N.M.; Inagami, T.; Misono, K.; Kuczenski, R.
    Purification and characterization of rat striatal tyrosine hydroxylase. Comparison of the activation by cyclic AMP-dependent phosphorylation and by other effectors (1985), J. Biol. Chem., 260, 8465-8473.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
heparin 0.1 mg/ml, activates Rattus norvegicus
additional information activation by phosphorylation Rattus norvegicus
phosphatidylinositol 0.1 mg/ml activates Rattus norvegicus

General Stability

General Stability Organism
heparin stabilizes Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
NaCl activates Rattus norvegicus
phosphate 1 mol per mol of subunit Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
sucrose density gradient centrifugation Rattus norvegicus
60000
-
4 * 60000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
striatum
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6
-
purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 6-methyltetrahydropterin + O2
-
Rattus norvegicus ?
-
?
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O 3,4-dihydroxy-L-phenylalanine is identical with dopa ?

Subunits

Subunits Comment Organism
tetramer 4 * 60000, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
unstable in presence of phosphatidylinositol or NaCl at high concentration, but relatively stable in presence of heparin Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.9
-
nonphosphorylated enzyme Rattus norvegicus
6.2
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5.9 7.4 activity declines precipitously below pH 5.9 and above pH 7.4 Rattus norvegicus