Activating Compound | Comment | Organism | Structure |
---|---|---|---|
estradiol-17beta | biphasic effects on in vivo and in vitro enzyme activity and kinetics. Low concentrations (1 nM) stimulate, and high concentrations (1 mM) inhibit | Heteropneustes fossilis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estradiol-17beta | biphasic effects on in vivo and in vitro enzyme activity and kinetics. Low concentrations (1 nM) stimulate, and high concentrations (1 mM) inhibit | Heteropneustes fossilis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
L-tyrosine | 30°C | Heteropneustes fossilis | |
0.34 | - |
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine | 30°C | Heteropneustes fossilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Heteropneustes fossilis | circulating titer of estradiol-17 beta can act differentially on the enzyme to alter catecholamineergic activity. Estradiol-17 beta may participate in the acute regulation of the enzyme by interacting with the cAMP signaling pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Heteropneustes fossilis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | - |
Heteropneustes fossilis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine + O2 | - |
Heteropneustes fossilis | 3,4-dihydroxy-L-phenylalanine + ? | - |
? | |
additional information | circulating titer of estradiol-17 beta can act differentially on the enzyme to alter catecholamineergic activity. Estradiol-17 beta may participate in the acute regulation of the enzyme by interacting with the cAMP signaling pathway | Heteropneustes fossilis | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydropteridine | - |
Heteropneustes fossilis |