General Stability | Organism |
---|---|
catecholamine binding improves tyrosine hydroxylase's resistance to proteolysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Catecholamines | e.g. dopamine, feedback inhibition, phosphorylation by protein kinase A at Ser40, the most prominent of these regulatory sites, increases the dissociation rate of bound catecholamine inhibitors | Homo sapiens | |
dopamine | binds to the iron ion at the active site | Homo sapiens | |
additional information | no inhibition by nonhydroxylated N-methyl-1,2,3,4-tetrahydroisoquinoline | Homo sapiens | |
N-methyl-norsalsolinol | noncompetitive with respect to L-tyrosine, N-methyl-norsalsolinol and related tetrahydroisoquinolines accumulate in the nigrostriatal system of the human brain and are increased in the cerebrospinal fluid of patients with Parkinsons disease | Homo sapiens | |
N-methyl-salsolinol | - |
Homo sapiens | |
norsalsolinol | N-methyl-norsalsolinol and related tetrahydroisoquinolines accumulate in the nigrostriatal system of the human brain and are increased in the cerebrospinal fluid of patients with Parkinsons disease | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | localized at the active site, the ferric is the inactive state, modelling of catecholamine and 6,7-dihydroxylated tetrahydroisoquinoline inhibitor docking to the active site Fe2+, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | key enzyme in dopamine synthesis, negative catecholamine end-product regulation, overview | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes TH1 and TH4 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | enzyme activation by reversible phosphorylation, phosphorylation by protein kinase A at Ser40, the most prominent of these regulatory sites, increases the dissociation rate of bound catecholamine feedback inhibitors | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | key enzyme in dopamine synthesis, negative catecholamine end-product regulation, overview | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
5 h, stable, catecholamine, N-methyl-norsalsolinol, or norsalsolinol binding increases the thermal stability of tyrosine hydroxylase | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
- |
Homo sapiens | dopamine | |
0.0003 | - |
- |
Homo sapiens | N-methyl-norsalsolinol | |
0.004 | - |
- |
Homo sapiens | N-methyl-salsolinol | |
0.01 | - |
- |
Homo sapiens | norsalsolinol |