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Literature summary for 1.14.16.2 extracted from

  • Chevalier, J.; Derkinderen, P.; Gomes, P.; Thinard, R.; Naveilhan, P.; Vanden Berghe, P.; Neunlist, M.
    Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system (2008), J. Physiol., 586, 1963-1975.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.16.2

Activating Compound

Activating Compound Comment Organism Structure
additional information KCl induces the enzyme through activation of protein kinase C and protein kinase A, inhibition of induction by inhibitors H89 and SQ22536, but not by inhibitor PP2, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus
-
 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
additional information Rattus norvegicus neuronal activity, modulated e.g. by KCl, mediates changes in TH expression, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 pregnant Sprague-Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
enteric nervous system
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 Rattus norvegicus
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neuron olfactory and sensory neurons, cholinergic and adrenergic pathways modulate the proprotion of tyrosine hydroxylase-immunoreactive neurons, KCl induces the number of positive TH-IR neurons involving L-type Ca2+ channels, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
 Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
 ?
additional information neuronal activity, modulated e.g. by KCl, mediates changes in TH expression, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
 Rattus norvegicus