Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cyclin-dependent kinase 5 phosphorylates tyrosine hydroxylase, but does not induce the enzyme expression | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the pogo/pogo mouse phenotype of ataxic mice shows upregulation of tyrosine hydroxylase expression induced by enzyme phosphorylation via cyclin-dependent kinase 5, reduced Cdk5 activity in both p35-/- and p39-/- cerebellum do not correspond to defects in tyrosine hydroxylase expression, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Mus musculus | the enzyme expression is increased in ataxic mice, Cdk5 activity cannot account for abnormal tyrosine hydroxylase expression in the cerebellum | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | cyclin-dependent kinase 5 phosphorylates tyrosine hydroxylase, but does not induce the enzyme expression | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | ataxic and control, high enzyme expression level in ataxic mice, dramatic difference in cerebellar tyrosine hydroxylase immunoreactivity between mutant pogo, wild-type, and mutant p35-/- and p39-/- mice, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Mus musculus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | the enzyme expression is increased in ataxic mice, Cdk5 activity cannot account for abnormal tyrosine hydroxylase expression in the cerebellum | Mus musculus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Mus musculus |