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Literature summary for 1.14.16.2 extracted from

  • Chen, X.; Xu, L.; Radcliffe, P.; Sun, B.; Tank, A.W.
    Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons (2008), Mol. Pharmacol., 73, 1816-1828.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate i.e. 8-CPTcAMP, tyrosine hydroxylase protein level and activity rate are increased in MN9D cells in response to treatment with 8-CPTcAMP, mechanism, overview Mus musculus
forskolin i.e. 8-CPTcAMP, tyrosine hydroxylase protein level and activity rate are increased in MN9D cells in response to treatment with 8-CPTcAMP, mechanism, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of an enzyme-luciferase fusion protein in MN9D cells, quantitative PCR-based enzyme expression analysis, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2 Mus musculus
-
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?
L-tyrosine + tetrahydrobiopterin + O2 Rattus norvegicus
-
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
midbrain midbrain dopaminergic neurons, expression analysis in situ Rattus norvegicus
-
MN9D cell a hybrid cell line derived from the fusion of mouse neuroblastoma N18TG2 cells with embryonic mouse mesencephalic neurons, tyrosine hydroxylase polysome profile analysis, overview Mus musculus
-
N18TG2 cell
-
Mus musculus
-
neuron midbrain dopaminergic neurons, expression analysis in situ Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Mus musculus
additional information
-
-
Rattus norvegicus
0.0002
-
about, MN9D cells Mus musculus
0.00045
-
about, MN9D cells induced by forskolin or 8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 6-methyltetrahydrobiopterin + O2
-
Mus musculus 3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin
-
?
L-tyrosine + 6-methyltetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 6-methyl-4a-hydroxytetrahydrobiopterin
-
?
L-tyrosine + tetrahydrobiopterin + O2
-
Mus musculus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
Mus musculus
tyrosine hydroxylase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Mus musculus
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Mus musculus
6.8
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
6-Methyl-5,6,7,8-tetrahydropterin
-
Mus musculus
6-Methyl-5,6,7,8-tetrahydropterin
-
Rattus norvegicus
tetrahydrobiopterin
-
Mus musculus
tetrahydrobiopterin
-
Rattus norvegicus