Cloned (Comment) | Organism |
---|---|
expression of gene fragment, comprising positions -495 to +25, which have regulatory promoter function, from a pGL-Basic luciferase reporter vector in MES23.5 cells and MES23.5 alpha-synuclein-overexpressing cells, alpha-synuclein is a negative regulator of the tyrosine hydroxylase expression via trans-acting function on the TH promoter, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | alpha-synuclein is a negative regulator of the enzyme and the dopamine biosynthesis pathway | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? | |
L-tyrosine + tetrahydrobiopterin + O2 | alpha-synuclein is a negative regulator of the enzyme and the dopamine biosynthesis pathway | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Homo sapiens |