Literature summary for 1.14.16.2 extracted from

Klongpanichapak, S.; Phansuwan-Pujito, P.; Ebadi, M.; Govitrapong, P.
Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells (2008), Neurosci. Lett., 436, 309-313.

Search for more literature for 1.14.16.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	phosphorylation at Ser40 activates the enzyme, the phosphorylation is inhibited by alpha-synuclein, up to 183% induced by amphetamines, the phosphorylation inhibition is inhibited by melatonin, mechanisms, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	phosphorylation at Ser40 activates the enzyme, the phosphorylation is inhibited by alpha-synuclein, up to 183% induced by amphetamines, the phosphorylation inhibition is inhibited by melatonin, mechanisms, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Homo sapiens	key and rate-limiting enzyme in dopamine and other catecholamine biosynthesis, regulation, mechanisms, overview	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation at Ser40 activates the enzyme, the phosphorylationis inhibited by alpha-synuclein, up to 183% induced by amphetamines, the phosphorylation inhibition is inhibited by melatonin, mechanisms, overview	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
neuron	-	Homo sapiens	-
SK-N-SH cell	a dopaminergic cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Homo sapiens	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	key and rate-limiting enzyme in dopamine and other catecholamine biosynthesis, regulation, mechanisms, overview	Homo sapiens	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O	-	?

Synonyms

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
tetrahydrobiopterin	-	Homo sapiens

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Release 2023.1 (January 2023)