Literature summary for 1.14.16.2 extracted from

Gruntenko, N.E.; Karpova, E.K.; Chentsova, N.A.; Adonyeva, N.V.; Rauschenbach, I.Y.
20-hydroxyecdysone and juvenile hormone influence tyrosine hydroxylase activity in Drosophila females under normal and heat stress conditions (2009), Arch. Insect Biochem. Physiol., 72, 263-272.

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Activating Compound

Activating Compound	Comment	Organism	Structure
20-hydroxyecdysone	20-hydroxyecdysone feeding (0.06 mg) leads to a substantial rise in tyrosine hydroxylase activity	Drosophila melanogaster
20-hydroxyecdysone	20-hydroxyecdysone feeding (0.06 mg) leads to a substantial rise in tyrosine hydroxylase activity	Drosophila virilis
juvenile hormone-III	0.0001 or 0.0002 mg juvenile hormone-III application leads to a substantial rise in tyrosine hydroxylase activity	Drosophila melanogaster
juvenile hormone-III	0.0001 or 0.0002 mg juvenile hormone-III application leads to a substantial rise in tyrosine hydroxylase activity	Drosophila virilis

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-
Drosophila melanogaster Canton S	-	-	-
Drosophila virilis	-	-	-
Drosophila virilis 101	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + 5,6,7,8-tetrahydro-L-biopterin + O2	-	Drosophila melanogaster	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydro-L-biopterin	-	?
L-tyrosine + 5,6,7,8-tetrahydro-L-biopterin + O2	-	Drosophila virilis	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydro-L-biopterin	-	?
L-tyrosine + 5,6,7,8-tetrahydro-L-biopterin + O2	-	Drosophila melanogaster Canton S	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydro-L-biopterin	-	?
L-tyrosine + 5,6,7,8-tetrahydro-L-biopterin + O2	-	Drosophila virilis 101	3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydro-L-biopterin	-	?

Synonyms

Synonyms	Comment	Organism
tyrosine hydroxylase	-	Drosophila melanogaster
tyrosine hydroxylase	-	Drosophila virilis

Cofactor

Cofactor	Comment	Organism	Structure
5,6,7,8-tetrahydro-L-biopterin	-	Drosophila melanogaster
5,6,7,8-tetrahydro-L-biopterin	-	Drosophila virilis

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Release 2023.1 (January 2023)