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Literature summary for 1.14.16.2 extracted from
- Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis (2008), J. Biol. Chem., 283, 31449-31459.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GTP cyclohydrolase I | as concentrations of 5,6,7,8-tetrahydrobiopterin are increased (0.025 and 0.1 mM), the specific activity of tyrosine hydroxylase is stimulated in the presence of GTP cyclohydrolase I isoform C | Drosophila melanogaster |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3)pLysS cells | Drosophila melanogaster |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dopamine | feedback inhibition, in the presence of 0.02 mM dopamine tyrosine hydroxylase enzyme specific activity is reduced by about 60% | Drosophila melanogaster |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Drosophila melanogaster | tyrosine hydroxylase stimulates GTP cyclohydrolase I activity | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation and Sephacryl S-300HR gel filtration | Drosophila melanogaster |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| head | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + 5,6,7,8-tetrahydrobiopterin + O2 | - |
Drosophila melanogaster | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin | - |
? | |
| additional information | tyrosine hydroxylase stimulates GTP cyclohydrolase I activity | Drosophila melanogaster | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tyrosine hydroxylase | - |
Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| tetrahydrobiopterin | - |
Drosophila melanogaster | |
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