Protein Variants | Comment | Organism |
---|---|---|
DELTA1-120 | not inhibited by dopamine | Rattus norvegicus |
DELTA1-32 | 90% inhibited by dopamine | Rattus norvegicus |
DELTA1-68 | not inhibited by dopamine | Rattus norvegicus |
DELTA1-76 | not inhibited by dopamine | Rattus norvegicus |
S19E | investigation of regulation by phosphorylation | Rattus norvegicus |
S19E/S40E | investigation of regulation by phosphorylation, slight decrease in KM value for tetrahydrobiopterin, slight increase in Vmax value | Rattus norvegicus |
S31E | good mimic of phosphorylated wild type protein | Rattus norvegicus |
S40E | good mimic of phosphorylated wild type protein | Rattus norvegicus |
S8E | investigation of regulation by phosphorylation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dopamine | feedback inhibitor, competitively with tetrahydrobiopterin | Rattus norvegicus | |
epinephrine | feedback inhibitor | Rattus norvegicus | |
norepinephrine | feedback inhibitor | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosine hydroxylase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | rate-limiting enzyme of catecholamine biosynthesis, regulated by phosphorylation, phosphorylation of Ser40 results in a decrease in affinity for catecholamines, phosphorylation of Ser31 results in a decrease in KM value for tetrahydrobiopterin, modified in the presence of NO, resulting in nitration of tyrosine residues (loss of activity) and the glutathionylation of cysteine residues | Rattus norvegicus |