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Literature summary for 1.14.16.2 extracted from

  • Daubner, S.C.; Le, T.; Wang, S.
    Tyrosine hydroxylase and regulation of dopamine synthesis (2011), Arch. Biochem. Biophys., 508, 1-12.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
DELTA1-120 not inhibited by dopamine Rattus norvegicus
DELTA1-32 90% inhibited by dopamine Rattus norvegicus
DELTA1-68 not inhibited by dopamine Rattus norvegicus
DELTA1-76 not inhibited by dopamine Rattus norvegicus
S19E investigation of regulation by phosphorylation Rattus norvegicus
S19E/S40E investigation of regulation by phosphorylation, slight decrease in KM value for tetrahydrobiopterin, slight increase in Vmax value Rattus norvegicus
S31E good mimic of phosphorylated wild type protein Rattus norvegicus
S40E good mimic of phosphorylated wild type protein Rattus norvegicus
S8E investigation of regulation by phosphorylation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
dopamine feedback inhibitor, competitively with tetrahydrobiopterin Rattus norvegicus
epinephrine feedback inhibitor Rattus norvegicus
norepinephrine feedback inhibitor Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Iron
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
-
?

Synonyms

Synonyms Comment Organism
tyrosine hydroxylase
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism rate-limiting enzyme of catecholamine biosynthesis, regulated by phosphorylation, phosphorylation of Ser40 results in a decrease in affinity for catecholamines, phosphorylation of Ser31 results in a decrease in KM value for tetrahydrobiopterin, modified in the presence of NO, resulting in nitration of tyrosine residues (loss of activity) and the glutathionylation of cysteine residues Rattus norvegicus