Any feedback?
Literature summary for 1.14.16.2 extracted from
- Mechanisms of tryptophan and tyrosine hydroxylase (2013), IUBMB Life, 65, 350-357.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tyrosine + tetrahydrobiopterin + O2 | Homo sapiens | the enzyme prefers L-tyrosine as a substrate over L-phenylalanine by an order of magnitude and over L-tryptophan by 25fold | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P07101 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine + tetrahydrobiopterin + O2 | the enzyme prefers L-tyrosine as a substrate over L-phenylalanine by an order of magnitude | Homo sapiens | L-tyrosine + 3-hydroxyphenylalanine + dihydropteridine + H2O | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | the enzyme prefers L-tyrosine as a substrate over L-tryptophan by 25fold | Homo sapiens | ? | - |
? | |
| L-tyrosine + tetrahydrobiopterin + O2 | the enzyme prefers L-tyrosine as a substrate over L-phenylalanine by an order of magnitude and over L-tryptophan by 25fold | Homo sapiens | 3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TyrH | - |
Homo sapiens |
| tyrosine hydroxylase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| additional information | a non-heme iron enzyme | Homo sapiens | |
| tetrahydrobiopterin | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
