Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iron chelators | - |
Bos taurus | |
iron chelators | - |
Canis lupus familiaris | |
iron chelators | - |
Oryctolagus cuniculus | |
iron chelators | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Rattus norvegicus | - |
- |
soluble | - |
Bos taurus | - |
- |
soluble | - |
Oryctolagus cuniculus | - |
- |
soluble | - |
Canis lupus familiaris | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | enzyme from pineal gland, stimulation | Rattus norvegicus | |
Fe2+ | enzyme from pineal gland, stimulation | Bos taurus | |
Fe2+ | enzyme from pineal gland, stimulation | Oryctolagus cuniculus | |
Fe2+ | enzyme from pineal gland, stimulation | Canis lupus familiaris | |
Fe2+ | some brain enzymes are stimulated others not | Rattus norvegicus | |
Fe2+ | some brain enzymes are stimulated others not | Bos taurus | |
Fe2+ | some brain enzymes are stimulated others not | Oryctolagus cuniculus | |
Fe2+ | some brain enzymes are stimulated others not | Canis lupus familiaris |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
57500 | - |
2 * 57500 + 2 * 60000, midbrain enzyme, SDS-PAGE | Oryctolagus cuniculus |
60000 | - |
2 * 57500 + 2 * 60000, midbrain enzyme, SDS-PAGE | Oryctolagus cuniculus |
220000 | 240000 | enzyme from hindbrain | Oryctolagus cuniculus |
288000 | - |
- |
Rattus norvegicus |
300000 | - |
- |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydropteridine + O2 | Rattus norvegicus | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | Bos taurus | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | Oryctolagus cuniculus | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | Canis lupus familiaris | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Canis lupus familiaris | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
tryptophan hydroxylase form I and II, pH 4.8, ammonium sulfate, gel filtration, DEAE-Sepharose, 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine-agarose | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
brain | - |
Bos taurus | - |
brain | - |
Oryctolagus cuniculus | - |
brain | activity in hypothalamus and midbrain-medulla regions, no activity in cerebellum or cortex | Canis lupus familiaris | - |
intestinal mucosa | - |
Rattus norvegicus | - |
intestinal mucosa | - |
Bos taurus | - |
intestinal mucosa | - |
Oryctolagus cuniculus | - |
intestinal mucosa | - |
Canis lupus familiaris | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Bos taurus | - |
liver | - |
Oryctolagus cuniculus | - |
liver | - |
Canis lupus familiaris | - |
pineal gland | - |
Rattus norvegicus | - |
pineal gland | - |
Bos taurus | - |
pineal gland | - |
Oryctolagus cuniculus | - |
pineal gland | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydropteridine + O2 | - |
Rattus norvegicus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | - |
Bos taurus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | - |
Oryctolagus cuniculus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | - |
Canis lupus familiaris | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Rattus norvegicus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Bos taurus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Oryctolagus cuniculus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | enzyme catalyzes the rate-limiting step in biosynthesis of putative neurotransmitter 5-hydroxytryptamine, serotonin | Canis lupus familiaris | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Rattus norvegicus |
tetramer | 2 * 57500 + 2 * 60000, midbrain enzyme, SDS-PAGE | Oryctolagus cuniculus |