Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-Fluorotryptophan | 1 mM, 90% inhibition of pineal tryptophan hydroxylase | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
L-tryptophan | enzyme from pineal gland, cofactor tetrahydrobiopterin | Bos taurus | |
0.032 | - |
L-phenylalanine | enzyme from pineal gland, cofactor tetrahydrobiopterin | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
enzyme from pineal gland, gel filtration, sucrose density gradient ultracentrifugation | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
enzyme from pineal gland, ammonium sulfate, hydroxylapatite, P-cellulose, DEAE-cellulose, Sephadex G-200 | Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-tryptophan + a 5,6,7,8-tetrahydropteridine + O2 = 5-hydroxy-L-tryptophan + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | phenylalanine hydroxylase, EC 1.14.16.1 also catalyzes this reaction | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pineal gland | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.235 | - |
tryptophan hydroxylase from pineal gland | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydropteridine + O2 | at a comparable rate of L-tryptophan hydroxylation | Bos taurus | tyrosine + dihydropteridine + H2O | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | - |
Bos taurus | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |