Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(7R)-5,6,7,8-tetrahydrobiopterin | recombinant pinal enzyme, 2.1 mM, 50% inhibition | Homo sapiens | |
L-5-hydroxytryptophan | - |
Homo sapiens | |
phenylalanine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
L-tryptophan | cofactor (6R)-5,6,7,8-tetrahydrobipterin | Homo sapiens | |
0.023 | - |
L-tryptophan | cofactor 6-methyl-5,6,7,8-tetrahydrobipterin | Homo sapiens | |
0.045 | - |
(6R)-5,6,7,8-tetrahydrobiopterin | substrate tryptophan | Homo sapiens | |
0.075 | - |
6-methyl-5,6,7,8-tetrahydrobiopterin | substrate tryptophan | Homo sapiens | |
0.09 | - |
L-phenylalanine | cofactor (6R)-5,6,7,8-tetrahydrobipterin | Homo sapiens | |
2.1 | - |
(7R)-5,6,7,8-tetrahydrobiopterin | substrate tryptophan | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | recombinant pineal enzyme contains 0.2-0.3 mol of iron/mol of enzyme | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
4 * 50000, recombinant pineal enzyme, SDS-PAGE | Homo sapiens |
200000 | - |
recombinant pineal enzyme, gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant pineal enzyme, ammonium sulfate, Pterin-agarose, Sepharose | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.6 | - |
recombinant pineal enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + (7R)-5,6,7,8-tetrahydrobiopterine + O2 | - |
Homo sapiens | L-tyrosine + dihydropteridine + H2O | - |
r | |
L-tryptophan + 6-methyl-tetrahydropterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 6-methyl-4a-hydroxytetrahydropterin | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 50000, recombinant pineal enzyme, SDS-PAGE | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.035 | - |
L-5-hydroxytryptophan | - |
Homo sapiens | |
0.15 | - |
phenylalanine | - |
Homo sapiens |