Literature summary for 1.14.16.4 extracted from

Martinez, A.; Knappskog, P.M.; Haavik, J.
A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis (2001), Curr. Med. Chem., 8, 1077-1091.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
modeled structure based on the known crystal structures of phenylalanine hydroxylase and tyrosine hydroxylase	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3,4-methylenedioxymethamphetamine	inactivation of the enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydropteridine + O2	Homo sapiens	initial and uncommited step in the biosynthesis of melatonin	5-hydroxy-L-tryptophan + dihydropteridine + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydropteridine + O2	initial and uncommited step in the biosynthesis of melatonin	Homo sapiens	5-hydroxy-L-tryptophan + dihydropteridine + H2O	-	?

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Release 2023.1 (January 2023)