Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method, X-ray crystal structure of a truncated functional form of enzyme (DELTANH102-DELTACOOH402) with the bound cofactor analogue 7,8-dihydro-L-biopterin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-tryptophan | substrate inhibition above 0.07 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0078 | - |
L-tryptophan | doubly truncated enzyme form DELTANH102-DELTACOOH402 | Homo sapiens | |
0.0265 | - |
(6R)-L-erytho-5,6,7,8-tetrahydrobiopterin | doubly truncated enzyme form DELTANH102-DELTACOOH402 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydropteridine + O2 | Homo sapiens | rate-determining step of serotonin biosynthesis | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17752 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + (6R)-L-erytho-5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + ? | - |
? | |
L-tryptophan + tetrahydropteridine + O2 | rate-determining step of serotonin biosynthesis | Homo sapiens | 5-hydroxy-L-tryptophan + dihydropteridine + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TRpOH | - |
Homo sapiens |