Cloned (Comment) | Organism |
---|---|
expression in HeLa cells | Homo sapiens |
expression in HeLa cells | Rattus norvegicus |
TPH2, DNA and amino acid sequence determination and analysis, genotyping, expression of mutant Q468R in HeLa cells, overview | Pan troglodytes |
Protein Variants | Comment | Organism |
---|---|---|
C164A/G170A | mutations represent differences between the human and chimpanzee enzyme, activity similar to wild-type | Homo sapiens |
C164A/G170A/Q468R | mutations represent differences between the human and chimpanzee enzyme and a polymorphism at position 468 present in chimpanzees but not in humans. 1.4fold activity compared to wild-type | Homo sapiens |
Q486R | determination of a naturally occuring single nucleotide polymorphism at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain, determination of allele frequency, the mutation is a gain -of-function mutation leading to 20% increased activity, comparison to rat and human TPH2s, overview | Pan troglodytes |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Pan troglodytes | TPH2 is a rate-limiting enzyme of neuronal serotonin biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Callithrix jacchus | - |
- |
- |
Cephalopachus bancanus | - |
- |
- |
Gorilla gorilla | - |
- |
- |
Homo sapiens | - |
- |
- |
Hylobates agilis | - |
- |
- |
Macaca fuscata | - |
- |
- |
Mandrillus sphinx | - |
- |
- |
Otolemur crassicaudatus | - |
- |
- |
Pan troglodytes | - |
- |
- |
Pongo pygmaeus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | - |
Homo sapiens | - |
cell culture | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 | 1.3fold activity compared to the human tryptophan hydroxylase 2 | Rattus norvegicus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | - |
Pan troglodytes | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | TPH2 is a rate-limiting enzyme of neuronal serotonin biosynthesis | Pan troglodytes | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH2 | - |
Homo sapiens |
TPH2 | - |
Rattus norvegicus |
TPH2 | - |
Macaca fuscata |
TPH2 | - |
Pan troglodytes |
TPH2 | - |
Callithrix jacchus |
TPH2 | - |
Pongo pygmaeus |
TPH2 | - |
Cephalopachus bancanus |
TPH2 | - |
Otolemur crassicaudatus |
TPH2 | - |
Gorilla gorilla |
TPH2 | - |
Hylobates agilis |
TPH2 | - |
Mandrillus sphinx |
tryptophan hydroxylase 2 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Rattus norvegicus |
tryptophan hydroxylase 2 | - |
Macaca fuscata |
tryptophan hydroxylase 2 | - |
Pan troglodytes |
tryptophan hydroxylase 2 | - |
Callithrix jacchus |
tryptophan hydroxylase 2 | - |
Pongo pygmaeus |
tryptophan hydroxylase 2 | - |
Cephalopachus bancanus |
tryptophan hydroxylase 2 | - |
Otolemur crassicaudatus |
tryptophan hydroxylase 2 | - |
Gorilla gorilla |
tryptophan hydroxylase 2 | - |
Hylobates agilis |
tryptophan hydroxylase 2 | - |
Mandrillus sphinx |