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Literature summary for 1.14.16.4 extracted from

  • Wilson, S.T.; Stanley, B.; Brent, D.A.; Oquendo, M.A.; Huang, Y.Y.; Mann, J.J.
    The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder (2008), Am. J. Med. Genet., 150B, 202-208.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
genotyping of borderline personality disorder patients and healthy persons Homo sapiens

Protein Variants

Protein Variants Comment Organism
A218C a naturally occuring polymorphism associated with borderline personality disorder diagnosis, but not with suicidal behaviour, genotyping, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH is rate-limiting in serotonin biosynthesis 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
additional information Homo sapiens the borderline personality disorder might be partly due to serotonergic dysfunction ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
borderline patients
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
L-tryptophan + tetrahydrobiopterin + O2 TPH is rate-limiting in serotonin biosynthesis Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?
additional information the borderline personality disorder might be partly due to serotonergic dysfunction Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TPH1
-
Homo sapiens
tryptophan hydroxylase I
-
Homo sapiens