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Literature summary for 1.14.16.4 extracted from

  • Lin, Y.M.; Chao, S.C.; Chen, T.M.; Lai, T.J.; Chen, J.S.; Sun, H.S.
    Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese (2007), Arch. Gen. Psychiatry, 64, 1015-1024.
    View publication on PubMed
Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment) Organism
gene TPH1, DNA and amino acid sequence determination and analysis, genotyping in Han Chinese subjects Homo sapiens
gene TPH2, DNA and amino acid sequence determination and analysis, genotyping in Han Chinese subjects Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information screening for TPH2 polymorphisms in Han Chinese subjects, genotyping, haplotype frequency and association analysis, naturally occuring polymorphisms of TPH2 are A90G in the 5'-UTR of exon 1, C2755A in exon 2, C10662T in intron 4, G26270A in intron 5, G33775A in intron 6, G40237A in exon 7, A83610T in exon 9, and G93329A in the 3'-UTR of exon 11, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 Homo sapiens TPH2 is the first and rate-limiting enzyme in the serotonin biosynthetic pathway 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P17752 Han Chinese subjects, gene TPH1 encodes isozyme TPH1
-
Homo sapiens Q8IWU9 Han Chinese subjects, gene TPH2 encoding isozyme TPH2
-

Source Tissue

Source Tissue Comment Organism Textmining
brain stem raphe nuclei Homo sapiens
-
IMR-32 cell
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 TPH2 is the first and rate-limiting enzyme in the serotonin biosynthetic pathway Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

Synonyms Comment Organism
TPH1
-
 Homo sapiens
TPH2
-
 Homo sapiens
tryptophan hydroxylase 1
-
 Homo sapiens
tryptophan hydroxylase 2
-
 Homo sapiens