Literature summary for 1.14.16.4 extracted from

Liu, Q.; Yang, Q.; Sun, W.; Vogel, P.; Heydorn, W.; Yu, X.Q.; Hu, Z.; Yu, W.; Jonas, B.; Pineda, R.; Calderon-Gay, V.; Germann, M.; ONeill, E.; Brommage, R.; Cullinan, E.; Platt, K.; Wilson, A.; Powell, D.; Sands, A.; Zambrowicz, B.; Shi, Z.C.
Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract (2008), J. Pharmacol. Exp. Ther., 325, 47-55.

Search for more literature for 1.14.16.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression of isozymes TPH1 and TPH2 in Escherichia coli	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of Tph1 homozygous null mice from a 129S5/SvEvBrd and C57BL/6J hybrid background	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
LP-533401	-	Mus musculus
LP-615819	-	Mus musculus
additional information	development and pharmacokinetic and pharmacodynamic effects of inhibitors inhibiting specifically the enzyme in the gastrointestinal tract, inhibitory potency on different genotypes, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	Mus musculus	first and rate-limiting step in serotonin biosynthesis, serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter with both central and peripheral functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal sensation, secretion, and motility	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isozymes TPH1 and TPH2	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant isozymes TPH1 and TPH2 from Escherichia coli by pterin affinity chromatography	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
gastrointestinal tract	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + tetrahydrobiopterin + O2	-	Mus musculus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?
L-tryptophan + tetrahydrobiopterin + O2	first and rate-limiting step in serotonin biosynthesis, serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter with both central and peripheral functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal sensation, secretion, and motility	Mus musculus	5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin	-	?

Synonyms

Synonyms	Comment	Organism
TPH1	-	Mus musculus
TPH2	-	Mus musculus
tryptophan hydroxylase	-	Mus musculus

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Release 2023.1 (January 2023)