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Literature summary for 1.14.16.4 extracted from
- Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase (2007), Mol. Cell. Biochem., 295, 205-215.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| DTT | - |
Mus musculus |  |
| Fe(NH4)2(SO4)2 | - |
Mus musculus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| secondary structure of TPH1 RNA, overview | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mice deficient in TPH1 and serotonin exhibit a reduced risk of thrombosis and thromboembolism, development of antithrombotic hammerhead miniribozymes with site-specific cleavage activity against short synthetic Tph1 RNA substrates targeting peripheral tryptophan hydroxylase, method development and evaluation, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase, overview | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + tetrahydrobiopterin + O2 | Mus musculus | rate-limiting enzyme in serotonin biosynthesis, mice deficient in peripheral tryptophan hydroxylase and serotonin exhibit a reduced risk of thrombosis and thromboembolism | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + 6-methyl-tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 6-methyl-4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
| L-tryptophan + tetrahydrobiopterin + O2 | rate-limiting enzyme in serotonin biosynthesis, mice deficient in peripheral tryptophan hydroxylase and serotonin exhibit a reduced risk of thrombosis and thromboembolism | Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peripheral tryptophan hydroxylase | - |
Mus musculus |
| TPH | - |
Mus musculus |
| TPH1 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
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