Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Homo sapiens | the enzyme is rate-limiting in serotonin biosynthesis, deficient levels of serotonin are associated with suicide and depression | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | Homo sapiens | localized changes in TPH2 expression in specific subnuclei of the dorsal raphe nucleus suggest that the serotonergic compensatory mechanism in depression and suicide is specifically regulated within the DRN and has implications for regions innervated by this subnucleus, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IWU9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | dorsal and median raphe nuclei, in the dorsal raphe nucleus there are more serotonin neurons and more neuronal TPH2 expression postmortem in depressed suicides. Depressed suicides have 26.5% more TPH2 grain density per neuron in the DRN compared with matched controls | Homo sapiens | - |
brain stem | expression analysis | Homo sapiens | - |
neuron | TPH2, serotonergic neurons | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is rate-limiting in serotonin biosynthesis, deficient levels of serotonin are associated with suicide and depression | Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
additional information | localized changes in TPH2 expression in specific subnuclei of the dorsal raphe nucleus suggest that the serotonergic compensatory mechanism in depression and suicide is specifically regulated within the DRN and has implications for regions innervated by this subnucleus, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TPH | - |
Homo sapiens |
TPH2 | - |
Homo sapiens |
tryptophan hydroxylase | - |
Homo sapiens |
tryptophan hydroxylase-2 | - |
Homo sapiens |