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Literature summary for 1.14.16.4 extracted from

  • Saitoh, A.; Yamaguchi, K.; Tatsumi, Y.; Murasawa, H.; Nakatani, A.; Hirose, N.; Yamada, M.; Yamada, M.; Kamei, J.
    Effects of milnacipran and fluvoxamine on hyperemotional behaviors and the loss of tryptophan hydroxylase-positive cells in olfactory bulbectomized rats (2007), Psychopharmacology, 191, 857-865.
    View publication on PubMed
Search for more literature for 1.14.16.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2 Rattus norvegicus the enzyme is involved in emotional responses 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
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 ?
additional information Rattus norvegicus chronic treatment with milnacipran or fluvoxamine is effective to improve both the hyperemotional behavior and the loss of TPH-positive cells in olfactory bulbectomized rats, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain dorsal and median raphe Rattus norvegicus
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additional information olfactory bulbectomized rats, i.e. OBX rats, with olfactory bulbs removed by suction, no significant difference in the effects on TPH immunoreactivity in the median raphe of OBX rats between vehicle- and antidepressants-treated animals Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin + O2
-
 Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
L-tryptophan + tetrahydrobiopterin + O2 the enzyme is involved in emotional responses Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
additional information chronic treatment with milnacipran or fluvoxamine is effective to improve both the hyperemotional behavior and the loss of TPH-positive cells in olfactory bulbectomized rats, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
TPH
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 Rattus norvegicus
tryptophan hydroxylase
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 Rattus norvegicus