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Literature summary for 1.14.16.4 extracted from

  • Calvo, A.C.; Scherer, T.; Pey, A.L.; Ying, M.; Winge, I.; McKinney, J.; Haavik, J.; Thoeny, B.; Martinez, A.
    Effect of pharmacological chaperones on brain tyrosine hydroxylase and tryptophan hydroxylase 2 (2010), J. Neurochem., 114, 853-863.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
a His-tagged version and a maltose binding protein-fusion protein are expressed in Escherichia coli Homo sapiens

General Stability

General Stability Organism
3-amino-2-benzyl-7-nitro-4-(2-quinolyl)-1,2-dihydroisoquinolin-1-one strongly stabilizes the protein during denaturation by heat. Half-denaturation temperature increases from 55.5°C to 64.4°C in the presence of 0.1 mM 3-amino-2-benzyl-7-nitro-4-(2-quinolyl)-1,2-dihydroisoquinolin-1-one. Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + tetrahydrobiopterin
-
Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
tryptophan hydroxylase 2
-
Homo sapiens