Protein Variants | Comment | Organism |
---|---|---|
R441H | naturally occuring missense mutation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloro-L-phenylalanine | irreversible inhibitor | Homo sapiens | |
4-chloro-L-phenylalanine | irreversible inhibitor | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Mus musculus | |
Fe2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin | - |
Mus musculus | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin | - |
Homo sapiens | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tryptophan hydroxylase 1 | - |
Mus musculus |
tryptophan hydroxylase 1 | - |
Homo sapiens |
tryptophan hydroxylase 2 | - |
Mus musculus |
tryptophan hydroxylase 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | serveral single nucleotide polymorphisms are associated with depression, suicidal behavior and bipolar disorder | Homo sapiens |