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Literature summary for 1.14.17.1 extracted from

  • Slama, P.; Boucher, J.L.; Reglier, M.
    Aromatic N-hydroxyguanidines as new reduction cosubstrates for dopamine beta-hydroxylase (2004), Biochem. Biophys. Res. Commun., 316, 1081-1087.
    View publication on PubMed
Search for more literature for 1.14.17.1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.45
-
 1-(4-chlorophenyl)-3-hydroxyguanidine 5 mM tyramine Bos taurus
2.8
-
 1-hydroxy-3-(4-methoxyphenyl)guanidine pH 6.0, 28°C, 0.4 mM tyramine Bos taurus
4.3
-
 1-hydroxy-3-(4-methoxyphenyl)guanidine pH 6.0, 28°C, 1.0 mM tyramine Bos taurus
7.2
-
 1-hydroxy-3-(4-methoxyphenyl)guanidine pH 6.0, 28°C, 5.0 mM tyramine Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tyramine + ascorbate + O2
-
 Bos taurus octopamine + dehydroascorbate + H2O
-
 ?
tyramine + N-(4-chlorophenyl)-N'-hydroxyguanidine + O2
-
 Bos taurus octopamine + 1-(4-chlorophenyl)urea + (4-chlorophenyl)cyanamide + 1-oxo-2-(4-chlorophenyl)guanidine + H2O
-
 ?
tyramine + N-(4-isopropylphenyl)-N'-hydroxyguanidine + O2 33% of the activity with N-(4-methoxyphenyl)-N‘-hydroxyguanidine Bos taurus octopamine + 1-(4-isopropylphenyl)urea + (4-isopropylphenyl)cyanamide + 1-oxo-2-(4-isopropylphenyl)guanidine + H2O
-
 ?
tyramine + N-(4-methoxyphenyl)-N'-hydroxyguanidine + O2
-
 Bos taurus octopamine + 1-(4-methoxyphenyl)urea + (4-methoxyphenyl)cyanamide + 1-oxo-2-(4-methoxyphenyl)guanidine + H2O
-
 ?
tyramine + N-(4-methylphenyl)-N'-hydroxyguanidine + O2 116% of the activity with N-(4-methoxyphenyl)-N‘-hydroxyguanidine Bos taurus octopamine + 1-(4-methylphenyl)urea + (4-methylphenyl)cyanamide + 1-oxo-2-(4-methylphenyl)guanidine + H2O
-
 ?
tyramine + N-(4-trifluoromethylphenyl)-N'-hydroxyguanidine + O2 16% of the activity with N-(4-methoxyphenyl)-N‘-hydroxyguanidine Bos taurus octopamine + 1-(4-trifluoromethylphenyl)urea + (4-trifluoromethylphenyl)cyanamide + 1-oxo-2-(4-trifluoromethylphenyl)guanidine + H2O
-
 ?