Application | Comment | Organism |
---|---|---|
medicine | adequate dietary Cu is essential to support DBM function in vivo | Mus musculus |
medicine | adequate dietary Cu is essential to support DBM function in vivo | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | Cu deficiency limits DBM activity in vivo | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
75000 | - |
Western blot analysis | Mus musculus |
75000 | - |
Western blot analysis | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Hsd:ICR (CD-1) outbred albino mice, postnatal day 27 male mice and day 28 male mice | - |
Rattus norvegicus | - |
Holtzman rats, postnatal day 24 male rats and day 26 male rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Mus musculus | - |
adrenal gland | - |
Rattus norvegicus | - |
heart | lowest level of all tissues | Rattus norvegicus | - |
additional information | medulla oblongata/pons | Rattus norvegicus | - |
vas deferens | - |
Rattus norvegicus | - |
vas deferens | DBM protein is present in Cu-negative samples but not in Cu-positive samples | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
tyramine + ascorbate + O2 | - |
Mus musculus | octopamine + dehydroascorbate + H2O | - |
? | |
tyramine + ascorbate + O2 | - |
Rattus norvegicus | octopamine + dehydroascorbate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DBM | - |
Mus musculus |
DBM | - |
Rattus norvegicus |
dopamine beta-mono-oxygenase | - |
Mus musculus |
dopamine beta-mono-oxygenase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | Cu-negative samples have significantly higher DBM activity than Cu-positive samples in both adrenal glands (2.4fold) and medulla oblongata/pons (0.9fold), but not vas deferens. No correlation between higher DBM mRNA and lower noradrenaline in Cu-negative tissues | up |
Mus musculus | DBM protein abundance in adrenal glands is higher in the Cu-negative samples compared with Cu-positive samples | up |