Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-Tyr-Pro-Gly-Gly | inhibition of activity with D-Tyr-Val-Gly | Ovis aries | |
D-Tyr-Val-Gly | inhibition of activity with D-Tyr-Pro-Gly | Ovis aries | |
EDTA | - |
Ovis aries | |
NaN3 | - |
Ovis aries | |
p-hydroxymercuribenzoate | slightly | Ovis aries | |
phosphate | - |
Ovis aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.033 | - |
D-Tyr-Pro-Gly-Gly | assayed without ascorbate and catalase, brain enzyme | Ovis aries | |
0.068 | - |
D-Tyr-Pro-Gly-Gly | assayed without ascorbate and catalase, pituitary enzyme | Ovis aries | |
0.075 | - |
D-Tyr-Pro-Gly-Gly | assayed with ascorbate and 0.1mg/ml catalase, pituitary enzyme | Ovis aries | |
0.289 | - |
D-Tyr-Pro-Gly-Gly | assayed with ascorbate and 0.1 mg/ml catalase, brain enzyme | Ovis aries |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
secretory granule | synaptosomal and neurosecretory granules | Ovis aries | 30141 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | Cu2+ strongly stimulates activity | Ovis aries | |
Cu2+ | a copper protein | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidylglycine + ascorbate + O2 | Ovis aries | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | - |
Ovis aries | - |
pituitary gland | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
very low activity in crude subcellular preparations | Ovis aries |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Tyr-Pro-Gly-Gly + ascorbate + O2 | synthetic peptide | Ovis aries | D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
D-Tyr-Pro-Gly-Gly + ascorbate + O2 | optimal activity in sulfonic acid buffers | Ovis aries | D-Tyr-Pro-Gly-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
D-Tyr-Val-Gly + ascorbate + O2 | - |
Ovis aries | D-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | - |
Ovis aries | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | COOH-terminal glycine | Ovis aries | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
peptidylglycine alpha-amidating mono-oxygenase | - |
Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | dependent on Cu2+-concentration | Ovis aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | dependent on | Ovis aries |