Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
secretory granule | chromaffin granules | Homo sapiens | 30141 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptidylglycine + ascorbate + O2 | Homo sapiens | amidation of neurohormonal peptides | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchial cancer cell | - |
Homo sapiens | - |
gastric cancer cell | - |
Homo sapiens | - |
gastrinoma cell | - |
Homo sapiens | - |
intestinal cancer cell | - |
Homo sapiens | - |
medullary thyroid carcinoma cell | - |
Homo sapiens | - |
neuroendocrine tumor cell | - |
Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
peptidylglycine alpha-amidating and alpha-hydroxylating monooxygenase activities in several tumor tissue extracts, comparison with immunological analysis, overview, highest activity in medullary thyroid carcinoma | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-N-acetyl-Tyr-Val-Gly + ascorbate + O2 | - |
Homo sapiens | alpha-N-acetyl-Tyr-Val-2-hydroxyglycine + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | COOH-terminal glycine | Homo sapiens | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
peptidylglycine + ascorbate + O2 | amidation of neurohormonal peptides | Homo sapiens | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | dependent on | Homo sapiens |