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Literature summary for 1.14.17.3 extracted from

  • Francisco, W.A.; Wille, G.; Smith, A.J.; Merkler, D.J.; Klinman, J.P.
    Investigation of the pathway for inter-copper electron transfer in peptidylglycine alpha-amidating monooxygenase (2004), J. Am. Chem. Soc., 126, 13168-13169.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
vesicle neurosecretory Rattus norvegicus 31982
-

Metals/Ions

Metals/Ions Comment Organism Structure
copper inter-copper electron transfer, mechanism, structure, 2 copper atoms per enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme catalyzes the production of neurohormones and neurotransmitters ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O inter-copper electron transfer, interdomain structure Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
medullary carcinoma cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dansyl-Gly-Gly-Ser-CO-NH-CH2-COOH + ascorbate + O2 substrate contains either protium or deuterium at the CH2-group Rattus norvegicus ?
-
?
HOOC-NH-CH2-COOH + ascorbate + O2 substrate contains either protium or deuterium at the CH2-group Rattus norvegicus ?
-
?
additional information enzyme catalyzes the production of neurohormones and neurotransmitters Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PAM
-
Rattus norvegicus
peptidylglycine alpha-amidating monooxygenase
-
Rattus norvegicus
peptidylglycine alpha-hydroxylating monooxygenase
-
Rattus norvegicus
PHM
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
17
-
dansyl-Gly-Gly-Ser-CO-NH-CH2-COOH pH 6.0, 37°C, recombinant enzyme Rattus norvegicus
37
-
HOOC-NH-CH2-COOH pH 6.0, 37°C, recombinant enzyme Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ascorbate
-
Rattus norvegicus