Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme expression is induced by androgen-deprivation therapy | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
pharmacology | enzyme is an attractive target for development of anti-tumor compounds | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
copper | metalloenzyme, required for catalysis, bound at the active site | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | enzyme is required for amidation of autocrine growth factors causing proliferation in tumor cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[peptide]-glycine + 2 ascorbate + O2 = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H2O | detailed analysis of the reaction mechanism, reaction scheme, strictly ordered ping-pong kinetic mechanism in which ascorbate first reduces Cu(II) to Cu(I), semidehydroascorbate being released, after which the peptide binds and finally oxygen, active site structure | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate specificity | Rattus norvegicus | ? | - |
? | |
additional information | enzyme is required for amidation of autocrine growth factors causing proliferation in tumor cells | Rattus norvegicus | ? | - |
? | |
peptidylglycine + ascorbate + O2 | peptidylglycine alpha-hydroxylating monooxygenase reaction | Rattus norvegicus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | the carbinol is the substrate for the peptidylamidoglycolate lyase reaction, EC 4.3.2.5, forming glyoxylate and amidated peptide | ? |
Synonyms | Comment | Organism |
---|---|---|
bifunctional peptidylglycine alpha-amidating monooxygenase | - |
Rattus norvegicus |
PAM | - |
Rattus norvegicus |
PAM/PHM | - |
Rattus norvegicus |
peptidylglycine alpha-hydroxylating monooxygenase | - |
Rattus norvegicus |
PHM | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Rattus norvegicus |