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Literature summary for 1.14.17.3 extracted from
- Characterization of the peptidylglycine alpha-amidating monooxygenase (PAM) from the venom ducts of neogastropods, Conus bullatus and Conus geographus (2013), Toxicon, 74, 215-224.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Drosophila S2 cells | Conus geographus |
| expressed in Drosophila S2 cells | Conus bullatus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| secretory vesicle | - |
Conus geographus | 99503 | - |
| secretory vesicle | - |
Conus bullatus | 99503 | - |
| trans-Golgi network | - |
Conus geographus | 5802 | - |
| trans-Golgi network | - |
Conus bullatus | 5802 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidylglycine + ascorbate + O2 | Conus geographus | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? |  |
| peptidylglycine + ascorbate + O2 | Conus bullatus | - |
peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Conus bullatus | - |
- |
- |
| Conus geographus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom duct | - |
Conus geographus | - |
| venom duct | - |
Conus bullatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dansyl-YVG-COOH + ascorbate + O2 | - |
Conus geographus | dansyl-YV-NH2 + dehydroascorbate + H2O | - |
? | |
| dansyl-YVG-COOH + ascorbate + O2 | - |
Conus bullatus | dansyl-YV-NH2 + dehydroascorbate + H2O | - |
? | |
| additional information | PAM carries out two functions, peptidyl alpha-hydroxylating monooxygenase and peptidylamido-glycolate lyase activities | Conus geographus | ? | - |
? | |
| additional information | PAM carries out two functions, peptidyl alpha-hydroxylating monooxygenase and peptidylamido-glycolate lyase activities | Conus bullatus | ? | - |
? | |
| peptidylglycine + ascorbate + O2 | - |
Conus geographus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
| peptidylglycine + ascorbate + O2 | - |
Conus bullatus | peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAM | - |
Conus geographus |
| PAM | - |
Conus bullatus |
| peptidyl alpha-hydroxylating monooxygenase | - |
Conus geographus |
| peptidyl alpha-hydroxylating monooxygenase | - |
Conus bullatus |
| peptidylglycine alpha-amidating monooxygenase | - |
Conus geographus |
| peptidylglycine alpha-amidating monooxygenase | - |
Conus bullatus |
| PHM | - |
Conus geographus |
| PHM | - |
Conus bullatus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate | - |
Conus geographus | |
| ascorbate | - |
Conus bullatus | |
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Release 2023.1 (January 2023)
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