Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dihydroxyphenyl)ethyl]prop-2-enamide | 67% inhibition at 0.1 mM | Homo sapiens | |
(2E)-3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide | 100% inhibition at 0.1 mM | Homo sapiens | |
(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-phenylethyl)prop-2-enamide | 19% inhibition at 0.1 mM | Homo sapiens | |
(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]prop-2-enamide | 40% inhibition at 0.1 mM | Homo sapiens | |
(2E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]prop-2-enamide | 49% inhibition at 0.1 mM | Homo sapiens | |
(2E)-N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide | 62% inhibition at 0.1 mM | Homo sapiens | |
(2E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide | 25% inhibition at 0.1 mM | Homo sapiens | |
2-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acetamide | 34% inhibition at 0.1 mM | Homo sapiens | |
2-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]acetamide | 16% inhibition at 0.1 mM | Homo sapiens | |
3-(3,4-dihydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]propanamide | 94% inhibition at 0.1 mM | Homo sapiens | |
3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]propanamide | 28% inhibition at 0.1 mM | Homo sapiens | |
3-(4-hydroxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]propanamide | 96% inhibition at 0.1 mM | Homo sapiens | |
4-OH-cinnamic acid | 4% inhibition at 0.1 mM | Homo sapiens | |
caffeic acid | 10% inhibition at 0.1 mM | Homo sapiens | |
dopamine | 10% inhibition at 0.1 mM | Homo sapiens | |
ferulic acid | 12% inhibition at 0.1 mM | Homo sapiens | |
kojic acid | 20% inhibition at 0.1 mM | Homo sapiens | |
additional information | in vitro and in vivo inhibitory potency of natural compounds, inhibition of melanogenesis, overview; no inhibition by N-[2-(3,4-dihydroxyphenyl)ethyl]-2-(4-hydroxy-3-methoxyphenyl)acetamide at 0.1 mM | Homo sapiens | |
N-(4-coumaroyl)serotonin | isolated from safflower, Carthamus tinctorius L. | Homo sapiens | |
N-dihydrocaffeoyltyramine | complete inhibition at 0.1 mM | Homo sapiens | |
N-feruloylserotonin | isolated from safflower, Carthamus tinctorius L. | Homo sapiens | |
N-[2-(3,4-dihydroxyphenyl)ethyl]-3-(4-hydroxy-3-methoxyphenyl)propanamide | 42% inhibition at 0.1 mM | Homo sapiens | |
trans-N-caffeoyltyramine | complete inhibition at 0.1 mM | Homo sapiens | |
trans-N-dihydro-p-hydroxycinnamoyltyramine | complete inhibition at 0.1 mM | Homo sapiens | |
tyramine | 23% inhibition at 0.1 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + L-dopa + O2 | Homo sapiens | - |
L-dopa + dopaquinone + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tyrosine + L-dopa + O2 | - |
Homo sapiens | L-dopa + dopaquinone + H2O | - |
? | |
additional information | the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | cf. EC 1.10.3.1 | Homo sapiens |
tyrosinase | - |
Homo sapiens |