Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | THSG, one of six compounds isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and to treat skin depigmentation diseases in traditional Chinese medicine. Shows significant melanogenesis stimulation activities and significant activation effects on B16 cell tyrosinase. THSG is a potent activator of tyrosinase | Mus musculus | |
2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | THSG, one of six compounds isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and treat skin depigmentation diseases in traditional Chinese medicine. Showed most potent effects on tyrosinase activation and melanogenesis | Agaricus bisporus | |
8-MOP | shows significant activation effects on B16 cell tyrosinase | Mus musculus | |
Aloe-emodin | isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and to treat skin depigmentation diseases in traditional Chinese medicine. Shows slightly melanogenesis stimulation activities | Mus musculus | |
Aloe-emodin | shows mild activating effects on tyrosinase. Isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and treat skin depigmentation diseases in traditional Chinese medicine | Agaricus bisporus | |
chrysophanol | isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and to treat skin depigmentation diseases in traditional Chinese medicine. Shows significant melanogenesis stimulation activities | Mus musculus | |
chrysophanol | shows mild activating effects on tyrosinase. Isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and treat skin depigmentation diseases in traditional Chinese medicine | Agaricus bisporus | |
emodin | isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and to treat skin depigmentation diseases in traditional Chinese medicine. Shows significant melanogenesis stimulation activities | Mus musculus | |
emodin | shows mild activating effects on tyrosinase. Isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and treat skin depigmentation diseases in traditional Chinese medicine | Agaricus bisporus | |
physcion | isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and to treat skin depigmentation diseases in traditional Chinese medicine. Shows slightly melanogenesis stimulation activities | Mus musculus | |
physcion | shows mild activating effects on tyrosinase. Isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and treat skin depigmentation diseases in traditional Chinese medicine | Agaricus bisporus |
Application | Comment | Organism |
---|---|---|
drug development | tyrosinase is a key enzyme involved in melanin biosynthesis and of particular interest in repigmentation research | Mus musculus |
drug development | tyrosinase is a key enzyme involved in melanin biosynthesis and of particular interest in repigmentation research | Agaricus bisporus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gallic acid | significantly inhibited tyrosinase. Isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and treat skin depigmentation diseases in traditional Chinese medicine | Agaricus bisporus | |
gallic acid | significantly inhibited tyrosinase. Isolated from Radix polygoni multiflori, a herb used effectively to prevent graying and to treat skin depigmentation diseases in traditional Chinese medicine | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | catalyzing the rate-limiting step for melanin biosynthesis | ? | - |
? | |
additional information | Agaricus bisporus | catalyzing the rate-limiting step for melanin biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agaricus bisporus | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-16 cell | B16 melanoma cell | Mus musculus | - |
commercial preparation | - |
Agaricus bisporus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
100 U/ml mushroom tryrosinase | Agaricus bisporus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-dopa + 1/2 O2 | - |
Mus musculus | dopachrome + H2O | - |
? | |
L-dopa + 1/2 O2 | - |
Agaricus bisporus | L-dopachrome + H2O | - |
? | |
additional information | catalyzing the rate-limiting step for melanin biosynthesis | Mus musculus | ? | - |
? | |
additional information | catalyzing the rate-limiting step for melanin biosynthesis | Agaricus bisporus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Mus musculus |
tyrosinase | - |
Agaricus bisporus |