Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
melanosome | - |
Mus musculus | 42470 | - |
melanosome | to catalyse melanin synthesis, tyrosinase is subsequently reloaded with copper within specialized organelles called melanosomes, immunofluorescence microscopy | Mus musculus | 42470 | - |
additional information | tryrosinase is present but inactive in BLOC-1-deficient melanocytes | Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
copper | copper transporter ATP7A localizes to melanosomes in wildtype melanocytes. Copper restores in vitro tyrosinase activity in melanosomes of BLOC-1-deficient melanocytes, immunofluorescence microscopy | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
melanocyte cell lines | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dopa + 1/2 O2 | - |
Mus musculus | dopaquinone + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tyrosinase | - |
Mus musculus |