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Literature summary for 1.14.18.1 extracted from

  • Wang, Y.; Curtis-Long, M.; Lee, B.; Yuk, H.; Kim, D.; Tan, X.; Park, K.
    Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots (2014), Bioorg. Med. Chem., 22, 1115-1120.
    View publication on PubMed
Search for more literature for 1.14.18.1

Inhibitors

Inhibitors Comment Organism Structure
flemichin D competitive inhibition Agaricus bisporus
fleminchalcone A i.e. 1-(5-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chroman-8-yl)-3-(4-methoxyphenyl)-propan-1-one, competitive inhibition Agaricus bisporus
fleminchalcone B i.e. 1-(3,5-dihydroxy-2,2-dimethylchroman-6-yl)-3-(4-methoxyphenyl)propan-1-one, competitive inhibition Agaricus bisporus
fleminchalcone C i.e. 1-(5-hydroxy-8-(2-hydroxypropan-2-yl)-2,2-dimethyl-7,8-dihydro-2H-furo[2,3-h]chromen-6-yl)-3-(4-methoxyphenyl)propan-1-one, competitive inhibition Agaricus bisporus
khonklonginol H competitive inhibition Agaricus bisporus
kojic acid
-
 Agaricus bisporus
lupinifolin competitive inhibition Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-DOPA + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?
L-tyrosine + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
L-tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00101
-
 with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus fleminchalcone A
0.00128
-
 with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus fleminchalcone C
0.00179
-
 with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus flemichin D
0.00496
-
 with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus khonklonginol H
0.00522
-
 with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus fleminchalcone C
0.00748
-
 with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus flemichin D
0.0112
-
 with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus lupinifolin
0.0123
-
 with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kojic acid
0.0184
-
 with L-tyrosine as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus fleminchalcone B
0.0195
-
 with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus fleminchalcone A
0.0204
-
 with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus khonklonginol H
0.0326
-
 with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus fleminchalcone B
0.0373
-
 with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kojic acid
0.0841
-
 with L-DOPA as substrate, in 0.05 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus lupinifolin