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Literature summary for 1.14.18.2 extracted from

  • Kawano, T.; Kozutsumi, Y.; Kawasaki, T.; Suzuki, A.
    Biosynthesis of N-glycolylneuraminic acid-containing glycoconjugates. Purification and characterization of the key enzyme of the cytidine monophospho-N-acetylneuraminic acid hydroxylation system (1994), J. Biol. Chem., 269, 9024-9029.
    View publication on PubMed

General Stability

General Stability Organism
enzyme is greatly stabilized by CMP-N-acetylneuraminate Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
CMP-N-acetylneuraminate pH 7.5, 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron contains non-heme iron as an electron acceptor Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
gel filtration Mus musculus
64000
-
1 * 64000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CMP-N-acetylneuraminate + NADH + O2 Mus musculus the enzyme is the key for regulation of the overall velocity of CMP-NeuAc hydroxylation and consequently for the expression of N-glycoloylneuraminic acid glycoconjugates CMP-N-glycoloylneuraminate + NAD+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.8
-
-
Mus musculus

Storage Stability

Storage Stability Organism
-80 C, 0.2 mM CMP-N-acetylneuraminate, stable for at least 6 months Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CMP-N-acetylneuraminate + NADH + O2
-
Mus musculus CMP-N-glycoloylneuraminate + NAD+ + H2O
-
?
CMP-N-acetylneuraminate + NADH + O2 the enzyme is the key for regulation of the overall velocity of CMP-NeuAc hydroxylation and consequently for the expression of N-glycoloylneuraminic acid glycoconjugates Mus musculus CMP-N-glycoloylneuraminate + NAD+ + H2O
-
?

Subunits

Subunits Comment Organism
monomer 1 * 64000, SDS-PAGE Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Mus musculus