Literature summary for 1.14.18.2 extracted from

Shaw, L.; Schneckenburger, P.; Carlsen, J.; Christiansen, K.; Schauer, R.
Mouse liver cytidine-5-monophosphate-N-acetylneuraminic acid hydroxylase. Catalytic function and regulation (1992), Eur. J. Biochem., 206, 269-277.

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Activating Compound

Activating Compound	Comment	Organism	Structure
decyl glucoside	activation	Mus musculus
additional information	highest activity in 50 mM Hepes buffer, significant inhibition at increasing concentrations	Mus musculus
Nonidet P-40	effective inhibitor	Mus musculus
octanoic acid	1 mM, modest activation	Mus musculus
octyl glucoside	effective inhibitor	Mus musculus
SDS	1 mM, modest activation	Mus musculus
Triton X-100	effective inhibitor	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
1,10-phenanthroline	5 mM, complete inhibition	Mus musculus
anti-(rat cytochrome b5) antiserum	-	Mus musculus
cardiolipin	3 mM, 15% inhibition	Mus musculus
CMP-N-glycoloylneuraminate	-	Mus musculus
ferrozine	0.7 mM, 82% inhibition	Mus musculus
KCN	5 mM, 49% inhibition	Mus musculus
Na2HPO4	2 mM, 86% inhibition	Mus musculus
Na4P2O7	2 mM, 54% loss of activity	Mus musculus
phosphatidic acid	3 mM, 20% inhibition	Mus musculus
phosphatidylinositol	3 mM, 68% inhibition	Mus musculus
Tiron	5 mM, 82% inhibition	Mus musculus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
17000	-	gel filtration	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CMP-N-acetylneuraminate + ferrocytochrome b5 + O2	the electron carrier cytochrome b5 is essential for activity	Mus musculus	CMP-N-glycoloylneuraminate + ferricytrochrome b5 + H2O	-	?
CMP-N-acetylneuraminate + NADH + O2	-	Mus musculus	CMP-N-glycoloylneuraminate + NAD+ + H2O	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.8	7.4	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ferrocytochrome b5	the electron carrier cytochrome b5 is essential for activity	Mus musculus
NADH	-	Mus musculus

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Release 2023.1 (January 2023)