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Literature summary for 1.14.18.5 extracted from
- Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation (2004), FEBS Lett., 563, 93-97.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293 cells | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
x * 35000, FLAG3-tagged enzyme, SDS-PAGE | Homo sapiens |
| 41200 | - |
x * 41200, estimated from amino acid sequence | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q6QHC5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| additional information | not detected in heart, liver, spleen, skeletal muscle, thymus or placenta | Homo sapiens | - |
| skin | highest expression in skin | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydroceramide + reduced acceptor + H+ + O2 | - |
Homo sapiens | phytoceramide + acceptor + H2O | - |
? |  |
| N-octanoyl-D-erythro-dihydrosphingosine + reduced acceptor + H+ + O2 | - |
Homo sapiens | ? | - |
? | |
| sphingosine + reduced acceptor + H+ + O2 | - |
Homo sapiens | phytosphingosine + acceptor + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 35000, FLAG3-tagged enzyme, SDS-PAGE | Homo sapiens |
| ? | x * 41200, estimated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DES2 | - |
Homo sapiens |
| dihydroceramide hydroxylase | - |
Homo sapiens |
| sphingolipid C4-hydroxylase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the enzyme is up-regulated during keratinocyte differentiation | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays an essential role in phytosphingolipid synthesis in human skin and other phytosphingolipid-containing tissues | Homo sapiens |
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