Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | O48916 | isoform FAH1 | - |
Arabidopsis thaliana | Q9SUC5 | isoform FAH2 | - |
Synonyms | Comment | Organism |
---|---|---|
FAH1 | - |
Arabidopsis thaliana |
FAH2 | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
physiological function | interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH1 mainly 2-hydroxylates very-long-chain fatty acids. In FAH1 knock-down lines, levels of hydroxylated fatty acids 22:0, 24:0, and 26:0 are considerably lower than in wild type, whereas the level of hydroxylated fatty acid 16:0 is marginally decreased. 2-Hydroxyfatty acids are related to resistance to oxidative stress, and isoform FAH1 or 2-hydroxy very-long-chain fatty acids show particularly strong responses to oxidative stress. Isoform FAH1 interacts with Bax inhibitor-1 via cytochrome b5 and is a key factor in Bax inhibitor-1-mediated cell death suppression | Arabidopsis thaliana |
physiological function | interaction with Arabidopsis cytochrome b5 is needed for sufficient activity. Isoform FAH2 selectively 2-hydroxylates palmitic acid in Arabidopsis. In FAH2 knock-down lines, the level of hydroxylated fatty acid 16:0 is reduced by 22.9%, whereas the levels of other 2-hydroxyfatty acids are similar to those in wild type | Arabidopsis thaliana |