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Literature summary for 1.14.19.1 extracted from
- A non-substrate-binding protein that stimulates microsomal stearyl-CoA desaturase (1981), Methods Enzymol., 71, 258-263.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| protein | non-substrate soluble cytosolic protein stimulates | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26500 | - |
gel filtration | Rattus norvegicus |
| 27000 | - |
1 * 27000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| stearoyl-CoA + AH2 + O2 | Rattus norvegicus | also other fatty acyl-CoA substrates | oleoyl-CoA + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley, male | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation, gel filtration, ultra filtration, ion-exchange | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O | multienzyme, insertion of a double bond in 9,10 position | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, microsomes, 24 hours, inhibition of desaturase by the cytosolic fraction rather than stimulation | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| stearoyl-CoA + AH2 + O2 | also other fatty acyl-CoA substrates | Rattus norvegicus | oleoyl-CoA + A + H2O | - |
? | |
| stearoyl-CoA + NADH + O2 | - |
Rattus norvegicus | oleoyl-CoA + NAD+ + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 27000, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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