Literature summary for 1.14.19.1 extracted from

Scaglia, N.; Igal, R.A.
Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells (2005), J. Biol. Chem., 280, 25339-25349.

Search for more literature for 1.14.19.1

Cloned(Commentary)

Cloned (Comment)	Organism
cDNA fragment corresponding to bp 278-2005 of the sequence was subcloned into a pcDNA3 vector in antisense orientation and stably transfected into SV40-WI38 lung fibroblasts cells, enzyme activity reduced in these stable cell clones, reduced protein level, reduced enzyme expression slows the rate of cell proliferation and suppresses anchorage-independent proliferation, SCD deficiency promotes apoptosis in a ceramide-independent manner	Homo sapiens

Cloned (Comment)

Organism

cDNA fragment corresponding to bp 278-2005 of the sequence was subcloned into a pcDNA3 vector in antisense orientation and stably transfected into SV40-WI38 lung fibroblasts cells, enzyme activity reduced in these stable cell clones, reduced protein level, reduced enzyme expression slows the rate of cell proliferation and suppresses anchorage-independent proliferation, SCD deficiency promotes apoptosis in a ceramide-independent manner

Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00767	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
WI-38 cell	SV40-transformed human lung fibroblasts, SV40-WI38	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
stearic acid + AH2 + O2	-	Homo sapiens	oleic acid + A + H2O	-	?

Synonyms

Synonyms	Comment	Organism
SCD	-	Homo sapiens

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Release 2023.1 (January 2023)