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Literature summary for 1.14.19.1 extracted from

  • Li, C.S.; Belair, L.; Guay, J.; Murgasva, R.; Sturkenboom, W.; Ramtohul, Y.K.; Zhang, L.; Huang, Z.
    Thiazole analog as stearoyl-CoA desaturase 1 inhibitor (2009), Bioorg. Med. Chem. Lett., 19, 5214-5217.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(1,3-thiazol-2-yl)-4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazine
-
Rattus norvegicus
2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide MF-152 Rattus norvegicus
2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxylic acid
-
Rattus norvegicus
2-[4-(phenylcarbonyl)piperazin-1-yl]-1,3-thiazole-5-carboxamide
-
Rattus norvegicus
6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
-
Rattus norvegicus
6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxylic acid
-
Rattus norvegicus
N-(2-cyclopropyl-2-hydroxyethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
-
Rattus norvegicus
N-(2-cyclopropylethyl)-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-4-carboxamide
-
Rattus norvegicus
N-(2-cyclopropylethyl)-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
-
Rattus norvegicus
N-methyl-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
delta-9 desaturase
-
Rattus norvegicus
DELTA9D
-
Rattus norvegicus
SCD1
-
Rattus norvegicus
stearoyl-CoA desaturase 1
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
-
Rattus norvegicus 2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
0.0007
-
-
Rattus norvegicus 6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
0.002
-
-
Rattus norvegicus N-methyl-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
0.002
-
-
Rattus norvegicus 2-[4-(phenylcarbonyl)piperazin-1-yl]-1,3-thiazole-5-carboxamide
0.0025
-
-
Rattus norvegicus N-(2-cyclopropyl-2-hydroxyethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
0.003
-
-
Rattus norvegicus 1-(1,3-thiazol-2-yl)-4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazine
0.007
-
-
Rattus norvegicus 2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxylic acid
0.037
-
-
Rattus norvegicus N-(2-cyclopropylethyl)-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
0.1
-
IC50 above 0.1 mM Rattus norvegicus 6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxylic acid
0.1
-
IC50 above 0.1 mM Rattus norvegicus N-(2-cyclopropylethyl)-2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-4-carboxamide