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Literature summary for 1.14.19.17 extracted from

  • Beauchamp, E.; Goenaga, D.; Le Bloch, J.; Catheline, D.; Legrand, P.; Rioux, V.
    Myristic acid increases the activity of dihydroceramide DELTA4-desaturase 1 through its N-terminal myristoylation (2007), Biochimie, 89, 1553-1561.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
myristic acid the activity of wild-type isoform DES1 is linearly increased in the presence of increased concentrations of myristic acid. The dihydroceramide DELTA4-desaturase activity of the myristoylable enzyme is reproducibly and significantly higher than the unmyristoylated enzyme Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in in Cos-7 cells Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
x * 40000, V5-His-tagged fusion protein, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydroceramide + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q5XIF5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroceramide + ferrocytochrome b5 + O2 + H+
-
Rattus norvegicus (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
?

Subunits

Subunits Comment Organism
? x * 40000, V5-His-tagged fusion protein, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
Degs1 isoform Rattus norvegicus
dihydroceramide DELTA4-desaturase 1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cytochrome b5
-
Rattus norvegicus