Activating Compound | Comment | Organism | Structure |
---|---|---|---|
myristic acid | the activity of wild-type isoform DES1 is linearly increased in the presence of increased concentrations of myristic acid. The dihydroceramide DELTA4-desaturase activity of the myristoylable enzyme is reproducibly and significantly higher than the unmyristoylated enzyme | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in in Cos-7 cells | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
x * 40000, V5-His-tagged fusion protein, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroceramide + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
(4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q5XIF5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroceramide + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, V5-His-tagged fusion protein, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
Degs1 | isoform | Rattus norvegicus |
dihydroceramide DELTA4-desaturase 1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome b5 | - |
Rattus norvegicus |