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Literature summary for 1.14.19.21 extracted from

  • Najle, S.R.; Nusblat, A.D.; Nudel, C.B.; Uttaro, A.D.
    The sterol-C7 desaturase from the ciliate Tetrahymena thermophila is a Rieske oxygenase, which is highly conserved in animals (2013), Mol. Biol. Evol., 30, 1630-1643.
    View publication on PubMed
Search for more literature for 1.14.19.21

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-cholest-22-en-3beta-ol + O2 + NADH + H+ Tetrahymena thermophila
-
 5alpha-cholesta-7,22-dien-3beta-ol + NAD+ + H2O
-
 ?
5alpha-cholest-22-en-3beta-ol + O2 + NADPH + H+ Tetrahymena thermophila
-
 5alpha-cholesta-7,22-dien-3beta-ol + NADP+ + H2O
-
 ?
5alpha-cholestan-3beta-ol + O2 + NADH + H+ Tetrahymena thermophila
-
 5alpha-cholest-7-en-3beta-ol + NAD+ + H2O
-
 ?
5alpha-cholestan-3beta-ol + O2 + NADPH + H+ Tetrahymena thermophila
-
 5alpha-cholest-7-en-3beta-ol + NADP+ + H2O
-
 ?
cholesta-5,22-dien-3beta-ol + O2 + NADH + H+ Tetrahymena thermophila
-
 cholesta-5,7,22-trien-3beta-ol + NAD+ + H2O
-
 ?
cholesta-5,22-dien-3beta-ol + O2 + NADPH + H+ Tetrahymena thermophila
-
 cholesta-5,7,22-trien-3beta-ol + NADP+ + H2O
-
 ?
cholesterol + O2 + NADH + H+ Tetrahymena thermophila
-
 cholesta-5,7-dien-3beta-ol + NAD+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+ Tetrahymena thermophila
-
 cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-cholest-22-en-3beta-ol + O2 + NADH + H+
-
 Tetrahymena thermophila 5alpha-cholesta-7,22-dien-3beta-ol + NAD+ + H2O
-
 ?
5alpha-cholest-22-en-3beta-ol + O2 + NADPH + H+
-
 Tetrahymena thermophila 5alpha-cholesta-7,22-dien-3beta-ol + NADP+ + H2O
-
 ?
5alpha-cholestan-3beta-ol + O2 + NADH + H+
-
 Tetrahymena thermophila 5alpha-cholest-7-en-3beta-ol + NAD+ + H2O
-
 ?
5alpha-cholestan-3beta-ol + O2 + NADPH + H+
-
 Tetrahymena thermophila 5alpha-cholest-7-en-3beta-ol + NADP+ + H2O
-
 ?
cholesta-5,22-dien-3beta-ol + O2 + NADH + H+
-
 Tetrahymena thermophila cholesta-5,7,22-trien-3beta-ol + NAD+ + H2O
-
 ?
cholesta-5,22-dien-3beta-ol + O2 + NADPH + H+
-
 Tetrahymena thermophila cholesta-5,7,22-trien-3beta-ol + NADP+ + H2O
-
 ?
cholestanol + O2 + NADPH + H+
-
 Tetrahymena thermophila cholesta-5,7,22-trien-3beta-ol + NADP+ + H2O main product ?
cholesterol + O2 + NADH + H+
-
 Tetrahymena thermophila cholesta-5,7-dien-3beta-ol + NAD+ + H2O
-
 ?
cholesterol + O2 + NADPH + H+
-
 Tetrahymena thermophila cholesta-5,7-dien-3beta-ol + NADP+ + H2O
-
 ?
stigmastanol + O2 + NADPH + H+
-
 Tetrahymena thermophila 5alpha-24-ethylcholest-7-en-3beta-ol + NADP+ + H2O main product ?
stigmasterol + O2 + NADPH + H+
-
 Tetrahymena thermophila (3beta,22E)-stigmasta-5,7,22-trien-3-ol + NADP+ + H2O main product ?

Synonyms

Synonyms Comment Organism
C7-Des
-
 Tetrahymena thermophila
Des7p
-
 Tetrahymena thermophila
sterol C7(8)-desaturase
-
 Tetrahymena thermophila

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Tetrahymena thermophila
NADPH
-
 Tetrahymena thermophila
[2Fe-2S]-center
-
 Tetrahymena thermophila